Sublethal Spinal Ketamine Produces Neuronal Apoptosis in Rat Pups

Sublethal spinal ketamine produces neuronal apoptosis in rat pups.

Sublethal Spinal Ketamine Produces Neuronal Apoptosis in Rat Pups

1. Gottschalk A, Ford JG, Regelin CC, You J, Mascha EJ, Sessler DI, Durieux ME, Nemergut EC: Association between epidural analgesia and cancer recurrence after colorectal cancer surgery. ANESTHESIOLOGY 2010; 113:27–34 2. Christopherson R, James KE, Tableman M, Marshall P, Johnson FE: Long-term survival after colon cancer surgery: A variation associated with choice of anesthesia. Anesth Analg 20...

Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome.

BACKGROUND Systemic ketamine can trigger apoptosis in the brain of rodents and primates during susceptible developmental periods. Clinically, spinally administered ketamine may improve the duration or quality of analgesia in children. Ketamine-induced spinal cord toxicity has been reported in adult animals but has not been systematically studied in early development. METHODS In anesthetized r...

Bcl-2 in suppressing neuronal apoptosis after spinal cord injury.

BACKGROUND Apoptosis plays an important role in central neural diseases and trauma. B-cell lymphoma/Leukemia-2 (Bcl-2) can inhibit apoptosis in a wide variety of cells including neurons. In this experiment, by studying Bcl-2 over-expression transgenic (TG) mice subjected to spinal cord injury (SCI), we investigated whether Bcl-2 could reduce posttraumatic neuronal apoptosis, reduce the range of...

Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups.

OBJECTIVE Status Epilepticus (SE) is common in neonates and infants, and is associated with neuronal injury and adverse developmental outcomes. However, the role of SE in this injury is uncertain. Until now, we have lacked an animal model in which seizures result in neuronal injury in rodent models at ages below postnatal day 12 (P12) unless seizures are combined with inflammatory stressors. ...